ESPECIALIDADES lunes, 4 de julio de 2022  
Medicina regenerativa
Medicina regenerativa
Portal de Infomed
 
 
Total de artículos: 75 mostrando: 11 - 20

página 2 de 8   1  2  3  4  5  6  7  8  
Titulares

Monocytes-macrophages that express ?-smooth muscle actin preserve primitive hematopoietic cells in the bone marrow.Nat Immunol. 2012

Nat Immunol. 2012 Nov;13(11):1072-82. doi: 10.1038/ni.2408. Epub 2012 Sep 16.
Monocytes-macrophages that express ?-smooth muscle actin preserve primitive hematopoietic cells in the bone marrow.
Ludin A, Itkin T, Gur-Cohen S, Mildner A, Shezen E, Golan K, Kollet O, Kalinkovich A, Porat Z, D'Uva G, Schajnovitz A, Voronov E, Brenner DA, Apte RN, Jung S, Lapidot T.
SourceDepartment of Immunology, Weizmann Institute of Science, Rehovot, Israel.

Abstract
Hematopoietic stem and progenitor cells (HSPCs) are regulated by various bone marrow stromal cell types. Here we identified rare activated bone marrow monocytes and macrophages with high expression of ?-smooth muscle actin (?-SMA) and the cyclooxygenase COX-2 that were adjacent to primitive HSPCs. These myeloid cells resisted radiation-induced cell death and further upregulated COX-2 expression under stress conditions. COX-2-derived prostaglandin E(2) (PGE(2)) prevented HSPC exhaustion by limiting the production of reactive oxygen species (ROS) via inhibition of the kinase Akt and higher stromal-cell expression of the chemokine CXCL12, which is essential for stem-cell quiescence. Our study identifies a previously unknown subset of ?-SMA(+) activated monocytes and macrophages that maintain HSPCs and protect them from exhaustion during alarm situations


 
Total de artículos: 75 mostrando: 11 - 20

página 2 de 8   1  2  3  4  5  6  7  8  
 
: Editora Principal, Especialista de II Grado en Hematología, J' Dpto. Trasplante de Células Progenitoras Hematopoyéticas | - Instituto de Hematología e Inmunología, MINSAP | Calzada de Aldabo y Calle E. Altahabana, Ciudad de La Habana, 10300 Cuba Telefs: (537) 6431648 y (537) 6438042 Horario de atención: 8:30 AM a 5:00 PM, de Lunes a Viernes


Nosotros suscribimos Los Principios del código HONcode de la Fundación Salud en la Red
 Nosotros suscribimos
 los Principios
 HONcode.
 Compruébelo aquí
Webs Médicas de Calidad Contenido Digital Cubano 2005 Premio Stockholm Challenge 2002