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Mechanisms of Disease: Intravenous Immune Globulin in Autoimmune and Inflammatory Diseases
New England Journal of Medicine
Mechanisms of Disease: Intravenous Immune Globulin in Autoimmune and Inflammatory Diseases
 In an era in which new biologics are being introduced to target inflammation and autoimmunity, some older treatments persist. Immune globulin?replacement therapy has been a lifesaving treatment for patients with antibody deficiency. When immune globulin replacement was introduced in the 1950s for the treatment of primary immunodeficiency diseases, it was administered subcutaneously or by intramuscular injection; subsequently, preparations suitable for intravenous use were developed, and these have undergone progressive changes in composition, particularly the elimination of sugars and normalization of the salt content and osmolarity. As a result, reactions have become much less frequent.
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