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Medicina regenerativa
Medicina regenerativa
Portal de Infomed
 
 
Total de artículos: 75 mostrando: 51 - 60

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Titulares

Production of De Novo Cardiomyocytes: Human Pluripotent Stem Cell Differentiation and Direct Reprogramming.Cell Stem Cell, Volume 10, 1, 16-28, 6 January 2012

Authors
Paul W. Burridge, Gordon Keller, Joseph D. Gold, Joseph C. Wusend

Summary
Cardiovascular disease is a leading cause of death worldwide. The limited capability of heart tissue to regenerate has prompted methodological developments for creating de novo cardiomyocytes, both in vitro and in vivo. Beyond uses in cell replacement therapy, patient-specific cardiomyocytes may find applications in drug testing, drug discovery, and disease modeling. Recently, approaches for generating cardiomyocytes have expanded to encompass three major sources of starting cells: human pluripotent stem cells (hPSCs), adult heart-derived cardiac progenitor cells (CPCs), and reprogrammed fibroblasts. We discuss state-of-the-art methods for generating de novo cardiomyocytes from hPSCs and reprogrammed fibroblasts, highlighting potential applications and future challenges.


 
Total de artículos: 75 mostrando: 51 - 60

página 6 de 8   1  2  3  4  5  6  7  8  
 
: Editora Principal, Especialista de II Grado en Hematología, J' Dpto. Trasplante de Células Progenitoras Hematopoyéticas | - Instituto de Hematología e Inmunología, MINSAP | Calzada de Aldabo y Calle E. Altahabana, Ciudad de La Habana, 10300 Cuba Telefs: (537) 6431648 y (537) 6438042 Horario de atención: 8:30 AM a 5:00 PM, de Lunes a Viernes


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