viernes, 1 de julio de 2022
Portal de Infomed
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AgaDerm® (NVC-422 Gel)

AgaDerm Proven Effective Against All MRSA Strains in a Phase 2 Clinical Study

AgaDerm (NVC-422 Gel) represents a new class of topical anti-infectives known as Aganocides®, which were designed by NovaBay Pharmaceuticals, Inc., to mimic the body's natural defense against infection. Through a differentiated mechanism of action, Aganocides have been shown to be broadly effective against both Gram-positive and Gram-negative pathogens, and were proven safe and well tolerated in human clinical trials.

AgaDerm is in Phase 2 clinical development for treating impetigo, a highly contagious skin infection affecting children worldwide, which is caused by Staphylococcus aureus, including MRSA, Streptococcus pyogenes, or both. In a clinical study, AgaDerm demonstrated a 100% response rate for treating patients with impetigo caused by MRSA, whether MRSA was the sole organism or in a mixed infection. The study, which was published recently in the International Journal of Clinical and Experimental Pathology, also tested NVC-422 against 55 recent clinical isolates of MRSA acquired from a database of patients in the U.S. and Europe, where MRSA-USA300 is more prevalent. Again, NVC-422 was shown to be rapidly bactericidal against all bacterial isolates, regardless of resistance phenotype. Although the scope of the study did not specifically identify MRSA sub-types, it is very likely that the USA300 clone was represented in this population.


Total de artículos: 19 mostrando: 1 - 10

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: Editor principal, Especialista II grado en Dermatologia Investigador Agregado | Centro de Histoterapia Placentaria, BioCubaFarma | Calle 18 No. 4302 e/ 43 y 47, Playa, Ciudad de La Habana, CP, Cuba | Teléfs.: (537) 2042524 y (537) 2042383, Horario de atención: 8:30 a.m. a 3:00 p.m., de Lunes a Viernes

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