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Titulo: Molecular Analysis of Cancer
Autor: Jacqueline Boultwood, Carrie Fidler

Contenido:

Preface .................................................................................................v

Contributors ..........................................................................................ix

1 Molecular Analysis of Cancer: An Overview

Ken Wills..............................................................................................1

2 Detection of Chromosome Abnormalities in Leukemia Using

Fluorescence In Situ Hybridization

Lyndal Kearney, Sabrina Tosi, and Rina J. Jaju................................ 7

3 Spectral Karyotyping in Cancer Cytogenetics

Eva Hilgenfeld, Cristina Montagna, Hesed Padilla-Nash,

Linda Stapleton, Kerstin Heselmeyer-Haddad,

and Thomas Ried ............................................................................ 29

4 Comparative Genomic Hybridization Analysis

Binaifer R. Balsara, Jianming Pei, and Joseph R. Testa ................ 45

5 Detection of Chromosomal Deletions by Microsatellite Analysis

Rachel E. Ibbotson and Martin M. Corcoran .................................... 59

6 Detection and Quantification of Leukemia-Specific Rearrangements

Andreas Hochhaus .............................................................................. 67

7 Detection of t(2;5)(p23;q35) Translocation by Long-Range PCR

of Genomic DNA

Yunfang Jiang, L. Jeffrey Medeiros, and Andreas H. Sarris.......... 97

8 Use of DNA Fingerprinting to Detect Genetic Rearrangements

in Human Cancer

Vorapan Sirivatanauksorn, Yongyut Sirivatanauksorn,

Arthur B. McKie, and Nicholas R. Lemoine ............................... 107

9 Mutation Analysis of Large Genomic Regions in Tumor DNA Using

Single-Strand Conformation Polymorphism: Lessons from

the ATM Gene

Igor Vorechovsky ........................................................................... 115

10 Mutational Analysis of Oncogenes and Tumor Suppressor Genes

in Human Cancer Using Denaturing Gradient Gel Electrophoresis

Per Guldberg, Kirsten Grønbæk, Jesper Worm, Per thor Straten,

and Jesper Zeuthen ....................................................................... 125

11 Detection of Mutations in Human Cancer Using Nonisotopic

RNase Cleavage Assay

Marianna Goldrick and James Prescott ......................................... 141

12 Mutational Analysis of the Neurofibromatosis Type 1 Gene

in Childhood Myelodysplastic Syndromes Using a Protein

Truncation Assay

Lucy Side ....................................................................................... 157

13 Mutation Analysis of Cancer Using Automated Sequencing

Amanda Strickson and Carrie Fidler .............................................. 171

14 Detection of Differentially Expressed Genes in Cancer Using

Differential Display

Yineng Fu ....................................................................................... 179

15 Genomewide Gene Expression Analysis Using cDNA Microarrays

Chuang Fong Kong and David Bowtell........................................... 195

16 Gene Expression Profiling in Cancer Using cDNA Microarrays

Javed Khan, Lao H. Saal, Michael L. Bittner, Yuan Jiang,

Gerald C. Gooden, Arthur A. Glatfelter, and Paul S. Meltzer ..... 205

17 Wilms Tumor Gene WT1 as a Tumor Marker for Leukemic Blast Cells

and Its Role in Leukemogenesis

Haruo Sugiyama......................................................................... 223

18 Detection of Aberrant Methylation of the p15INK4B Gene Promoter

Toshiki Uchida ........................................................................... 239

19 Clonality Studies in Cancer Based on X Chromosome Inactivation

Phenomenon

John T. Phelan II and Josef T. Prchal ........................................251

20 Telomere Length Changes in Human Cancer

Dominique Broccoli and Andrew K. Godwin .............................271

21 Measurement of Telomerase Activity in Human Hematopoietic Cells

and Neoplastic Disorders

Kazuma Ohyashiki and Junko H. Ohyashiki .............................. 279

Index .......................................................................................... 301